Methacholine
-choline refers cholinomimetic agent (stuffs that act like acetylcholine that activates parasympathetic responses).

Meth- ; think of it as the addictive meth drug.

Minsoo thought meth was some sniffing sugar, so he tries to stiff it in. However, it turned out to be meth! So he coughs very bad.

Explanation;

Methacholine causes bronchoconstriction which is used for diagnostic purposes of asthma.

Neostigmine, Pyridostigmine
-stigmine; think of it as STIG MISSILE that destroys acetylcholinesterase. However, STIG MISSILE has some program errors so that it can only reversibly destroys acetylcholinesterase.

Neostigmine stimulates BenG because BenG likes to watch fireworks of STIG MISSILE destroying acetylcholinesterase. But BenG watches it too close and now screams NEEOOO! and runs strangely because he doesn’t want to get fireworks falling on top of his head and get damaged on his CNS. But Minsoo already saw some fireworks are about to fall on his head so the pilot Minsoo throws some mint pies at him to protect his head. Fortunately, BenG ‘s head is safe! Woo hoo!

Explanation;

Neostigmine stimulates the bladder and GI tract (BenG). It does not enter CNS. And it is used in treatment of myasthenia gravis, an autoimmune disease caused by antibodies to the nicotinic receptor at neuromuscular junctions. Its popular symptoms are weakness of eyes and limb muscles in which people walk strangely.

Pyridostigmine is another cholinesterase inhibitor that is used in the chronic management of myasthenia gravis. It also does not penetrate CNS.

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Minsoo