Sept 25, 2010 - Cytochrome P450

Just a small detour because this is really important. Certain drugs either induce or inhibit P-450 proteins of the liver. We need to have a general idea of the major ones that do this. I basically used First Aid and Kaplan and added the drugs together. I mostly used First Aid mnemonics and adjusted them slightly.

INDUCERS:

Quinidine

Barbiturates

St.John's Wart

Phenytoin

Rifampin

Griseofulvin

Carbamazepine

Chronic alcohol

Glucocorticoids

Queen Barb Steals Phen-Phen and Refuses Greasy Carbs, Chronic Alcohol, and Glucose.

(Queen Barb is really fat so she takes Phen-Phen and she refuses all the other things so she can get skinny) - Phen-Phen was a weight loss drug in the past

*Quinidine can be both an inducer or an inhibitor depending on the person's P-450 isoform. It is more commonly an inducer.

INHIBITORS:

Acute alcohol

Ketoconazole

Erythromycin (& other macrolides)

Grapefruit juice

Sulfonamides

Isoniazid

Cimetidine

Chloramphenicol

Omeprazol

Inhibit yourself from drinking Alcohol from a KEG. It will make you a SICCO!