Reminder: Location and action of Beta receptors:
B1= Heart (rate and force)
Juxtaglomerular cells (renin release)
B2= on smooth muscles of Lung, Uterus, Blood Vessels (relaxes)
Somatic Nerve Terminals (causes tremor)
Liver (Glycogenolysis)
Pancreas B cells (insulin release) ***** this is why Beta Antagonists cause Hyperglycemia!!
Drug names and types of Beta antagonists:
(1) Nonselective = Propranolol, Nadolol, Timolol, Pindolol
(2) B1 selective = Acebutolol, Atenolol, Metoprolol, Esmolol (only one that's only IV)
*Note: Selectivity is only true at low doses. According to the Professor the doses used
for treatment are really high
Uses for groups 1 &2
=Hypertension, Angina, Arrhythmia prophylaxis, Supraventricular tachycardia
(3) B and α antagonist = Labetalol and Carvedilol
-----> Used in Heart Failure (mechanism unknown)
Antiarrhythmic action: slows down AV conduction = prolonged PR interval on EKG
I think it's smart to memorize these drugs according to group!
Mnemonics = just looking at beginning of drug names since the all end with olol or ilol or alol. I made up silly sentences. Hopefully they're funny enough to remember :)
Nonselective: Propan, Nad, Tim, Pin
Nadalie, it's Time to play Pin the tail on the donkey. I'm nonselective about where I should Prop up the picture of the donkey.
B1 selective = Acebut, Aten, Metopro, Esm
Attention to all of the Essemblymen of the Metropolitan area, we Betta be #1 and Ace the Butt (Acebut) off our competition in the election poles.
B and α = Labet, Carved
Sharon Dagon just send out a new email: Groups α and B, please wear your Lab coat to Carvel this Friday. You don't want to break my heart (since it's used for heart failure)
Nice post! First, does anyone have a pdf of that popular EKG book?!
ReplyDeleteThis is how I remember it.
1) all B blockers starting with letter A to M are B1 selective (from Kaplan).
All the rest are nonselective.
or A BEAM of B1 blockers (from pharm recall)
- acebutalol, betaxolol, esmolol, atenolol, metoprolol
2) They all have sedative effects, but propanolol is the major one! Just think of sniffing a bunch of propane...it's going to make you really dizzy and tired.
3) acetbutalol and pindolol are partial agonists, to they don't show the full blocking effects
- imp points are that they don't increase lipids in blood (b/c of their B2 agonist metabolic effects)
Pindolol & Acetbutalol are Partial Agonists! (look at the letters..I couldn't bold them).
I meant Acebutalol ; ) ...not acetbutalol
ReplyDelete